ABSTRACT
Objective:To investigate the clinical effect of combination of aluminum magnesium carbonate and lansoprazole sodium in the treatment of gastric ulcer.Methods:From October 2017 to October 2018, 100 patients with gastric ulcer in Hangzhou Dajiangdong Hospital were randomly divided into control group and observation group by random number table method, with 50 cases in each group.The control group was treated with routine triple therapy, and the observation group was treated with aluminum magnesium carbonate combined with lansoprazole sodium capsule.The course of treatment in both two groups was eight weeks.The curative effect of the two groups was observed.Results:The total effective rate of the observation group was 96.0%(48/50), which was higher than that of the control group [70.0%(35/50)], the difference was statistically significant(χ 2=12.428, P<0.01). After treatment, the motilin, gastrin, percentages of collagen fiber area and neutral mucus area in the observation group were (255.22±36.29)ng/L, (142.19±9.86)μg/L, (46.29±5.27)%, (55.29±6.82)%, respectively, which were better than those in the control group [(281.73±30.84)ng/L, (114.58±8.35)μg/L, (35.69±4.38)%, (36.75±5.23)%], the differences were statistically significant( t=36.582, 31.125, 12.785, 21.745, all P<0.05). The scores of abdominal pain, belching, acid regurgitation and abdominal distension in the observation group were (1.46±0.52)points, (0.35±0.05)points, (0.49±0.13)points and (1.38±0.23)points, respectively, which were lower than those in the control group [(2.58±0.41)points, (1.46±0.71)points, (1.28±0.54)points and (2.65±0.48)points] ( t=1.836, 1.485, 1.023, 1.258, all P<0.05). The incidence of adverse reactions in the observation group[4.0%(2/50)] was lower than that in the control group [30.0%(15/50)](χ 2=14.258, P<0.01). Conclusion:The combination of magnesium aluminum carbonate and lansoprazole sodium has good clinical effect on gastric ulcer, which is superior to the conventional triple therapy.
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Objective To analyze the etiological and epidemiological characteristics of hand-foot-mouth disease(HFMD) in Liuzhou city from 2013 to 2016,and to provide scientific evidence for preventive policy making.Methods Specimens of HFMD cases were collected from the hospitals and county CDC from 2013 to 2016.The nucleic acids which are enterovirus viruses71(EV71),coxasckie virus A16(CoxA16) and other enterovirus(EV) was detected by Real time PCR technique.Results A total of 3 503 suspected HFMD cases were found,and 2 720 cases were identified.The main pathogen of HFMD in Liuzhou city was change every year from 2013 to 2016,in addition to EV71 and CoxA16,there was a higher proportion of EV.HFMD was a seasonal disease,most cases occurred from March to September.The children under 5 years old,especially 1-3 years old were the main patients,and male patients was higher than female.Severe and death HFMD was EV71,but death HFMD had no CoxA16.Conclusion EV was the main pathogen of mild HFMD in Liuzhou city from 2013 to 2016,but the pathogenic spectrum was changing every yeas.EV71 was the main pathogen of severe and death HFMD.
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Objective To investigated the etiologic characteristics of Shigella (S.) sonnei strains causing outbreaks and sporadic cases in some areas of Guangdong province and Guangxi Zhuang Autonomous Region during 2014-2016. Methods Fourteen S. sonnei strains isolated from outbreaks and 6 S. sonnei strains from sporadic cases from Guangdong and Liuzhou of Guangxi Zhuang Autonomous Region were tested for antimicrobial resistance and analyzed by pulsed-field gel electrophoresis (PFGE). Six typical strains were selected for whole genome sequencing typing and compared with 51 strains isolated both at home and abroad from NCBI genome database. Results The antibiotic resistance test indicated the isolates had high resistance rate to ampicillin, tetracycline, gentamicin, trimethoprim/sulfamethoxazole and nalidixic acid, while sensitive to azithromycin, chloromycetin and imipenem. PFGE showed high similarity (93.2%) among the strains isolated from different areas. The whole genome sequencing analysis also revealed that all the typical strains wereclustered into a same evolution branch, close to some strains from Korea. Conclusions The S. sonnei strains isolated from some areas of Guangdong and Guangxi Zhuang Autonomous Region showed high resistance to commonly used antibiotics, but they were sensitive to azithromycin, chloramphenicol and imipenem. The isolates in this study also showed similar PFGE patterns and close phylogenic evolution.
ABSTRACT
Objective To investigated the etiologic characteristics of Shigella (S.) sonnei strains causing outbreaks and sporadic cases in some areas of Guangdong province and Guangxi Zhuang Autonomous Region during 2014-2016. Methods Fourteen S. sonnei strains isolated from outbreaks and 6 S. sonnei strains from sporadic cases from Guangdong and Liuzhou of Guangxi Zhuang Autonomous Region were tested for antimicrobial resistance and analyzed by pulsed-field gel electrophoresis (PFGE). Six typical strains were selected for whole genome sequencing typing and compared with 51 strains isolated both at home and abroad from NCBI genome database. Results The antibiotic resistance test indicated the isolates had high resistance rate to ampicillin, tetracycline, gentamicin, trimethoprim/sulfamethoxazole and nalidixic acid, while sensitive to azithromycin, chloromycetin and imipenem. PFGE showed high similarity (93.2%) among the strains isolated from different areas. The whole genome sequencing analysis also revealed that all the typical strains wereclustered into a same evolution branch, close to some strains from Korea. Conclusions The S. sonnei strains isolated from some areas of Guangdong and Guangxi Zhuang Autonomous Region showed high resistance to commonly used antibiotics, but they were sensitive to azithromycin, chloramphenicol and imipenem. The isolates in this study also showed similar PFGE patterns and close phylogenic evolution.